The coming of age for Piwi proteins

被引：221

作者：

Seto, Anita G. ^{[1
]}

Kingston, Robert E. ^{[1
]}

Lau, Nelson C. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

来源：

MOLECULAR CELL | 2007年 / 26卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.molcel.2007.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Piwi proteins, a subfamily of Argonaute (Ago) proteins, have recently been shown to bind endogenous small RNAs. However, differences between Ago proteins (which bind microRNAs and small interfering RNAs) and Piwi proteins and Piwi-interacting RNAs (piRNAs) suggest novel functions for Piwi proteins. Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development.

引用

页码：603 / 609

页数：7

共 34 条

[1] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[2] A novel class of small RNAs bind to MILI protein in mouse testes [J].

Aravin, Alexei ;

Gaidatzis, Dimos ;

Pfeffer, Sebastien ;

Lagos-Quintana, Mariana ;

Landgraf, Pablo ;

Iovino, Nicola ;

Morris, Patricia ;

Brownstein, Michael J. ;

Kuramochi-Miyagawa, Satomi ;

Nakano, Toru ;

Chien, Minchen ;

Russo, James J. ;

Ju, Jingyue ;

Sheridan, Robert ;

Sander, Chris ;

Zavolan, Mihaela ;

Tuschl, Thomas .

NATURE, 2006, 442 (7099) :203-207

[3] Developmentally regulated piRNA clusters implicate MILI in transposon control [J].

Aravin, Alexei A. ;

Sachidanandam, Ravi ;

Girard, Angelique ;

Fejes-Toth, Katalin ;

Hannon, Gregory J. .

SCIENCE, 2007, 316 (5825) :744-747

[4] Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis [J].

Blumenstiel, JP ;

Hartl, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (44) :15965-15970

[5]

Brennecke J, 2007, CELL, V128, P1089, DOI 10.1016/j.cell.2007.01.043

[6] Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast [J].

Buker, Shane M. ;

Iida, Tetsushi ;

Buhler, Marc ;

Villen, Judit ;

Gygi, Steven P. ;

Nakayama, Jun-Ichi ;

Moazed, Danesh .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (03) :200-207

[7] The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis [J].

Carmell, MA ;

Xuan, ZY ;

Zhang, MQ ;

Hannon, GJ .

GENES & DEVELOPMENT, 2002, 16 (21) :2733-2742

[8] MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline [J].

Carmell, Michelle A. ;

Girard, Angelique ;

van de Kant, Henk J. G. ;

Bourc'his, Deborah ;

Bestor, Timothy H. ;

de Rooij, Dirk G. ;

Hannon, Gregory J. .

DEVELOPMENTAL CELL, 2007, 12 (04) :503-514

[9] A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal [J].

Cox, DN ;

Chao, A ;

Baker, J ;

Chang, L ;

Qiao, D ;

Lin, HF .

GENES & DEVELOPMENT, 1998, 12 (23) :3715-3727

[10]

Cox DN, 2000, DEVELOPMENT, V127, P503

← 1 2 3 4 →