Synthesis, resolution, and absolute configuration of two novel and selective cyclooxygenase-2 inhibitors based on the 1,5-diarylpyrrole structure

被引：16

作者：

Di Bari, Lorenzo

Pescitelli, Gennaro

Salvadori, Piero

Rovini, Michele

Anzini, Maurizio

Cappelli, Andrea

Vomero, Salvatore

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

[2] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

[3] Univ Siena, European Res Ctr Drug Discovery & Dev, I-53100 Siena, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 24期

关键词：

D O I：

10.1016/j.tetasy.2006.12.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

Three racemic esters based on the 1,5-diarylpyrrole structure, which proved to be highly selective COX-2 inhibitors endowed with an appreciable anti-inflammatory activity in some animal models, were subjected to chiral resolution. Their absolute configurations were assigned by comparison of the CD spectrum measured on-line with a HPLC-CD detector, with that calculated by means of a TDDFT method. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3430 / 3436

页数：7

共 40 条

[1]

GASTROINTESTINAL DAMAGE ASSOCIATED WITH THE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].