CCR5 receptor -: Biologic and genetic implications in age-related diseases

被引：53

作者：

Balistreri, Carmela Rita ^{[1
]}

Caruso, Calogero ^{[1
]}

Grimaldi, Maria Paola ^{[1
]}

Listi, Florinda ^{[1
]}

Vasto, Sonya ^{[1
]}

Orlando, Valentina ^{[1
]}

Campagna, Anna Maria ^{[1
]}

Lio, Domenico ^{[1
]}

Candore, Giuseppina ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Grp Studio Sull Immunosenescenza, I-90134 Palermo, Italy

来源：

BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS | 2007年 / 1100卷

关键词：

Alzheimer's disease; aging; cardiovascular disease; CCR5;

D O I：

10.1196/annals.1395.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein-coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Thl cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age-related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5 Delta 32 deletion and cardiovascular diseases and Alzheimer's disease.

引用

页码：162 / 172

页数：11

共 49 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].