IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http//imgt.cines.fr

被引：81

作者：

Lefranc, MP ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UPR 1142, Lab Immunogenet Mol,LIGM,IGH, F-34396 Montpellier 5, France

来源：

LEUKEMIA | 2003年 / 17卷 / 01期

关键词：

database; immunoglobulin; leukemia; lymphoma; rearrangement; T cell receptor;

D O I：

10.1038/sj.leu.2402637

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

IMGT, the international ImMunoGeneTics database((R)) (http://imgt.cines.fr), is a high-quality integrated information system specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) of human and other vertebrates, created in 1989, by LIGM, at the Universite Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT includes several databases (IMGT/LIGM-DB, IMGT/3Dstructure-DB, IMGT/HLA-DB), Web resources ('IMGT Marie-Paule page') and interactive tools (IMGTN-OUEST, IMGT/JunctionAnalysis). IMGT expertly annotated data and tools described in this paper are particularly useful for the analysis of the IG and TR rearrangements in leukemia, lymphoma and myeloma, and in translocations involving the antigen receptor loci. IMGT is freely available at http://imgt.cines.fr.

引用

页码：260 / 266

页数：7

共 50 条

[1]

[Anonymous], 2001, T CELL RECEPTOR FACT

[2] The Human Immunoglobulin Kappa Variable (IGKV) Genes and Joining (IGKJ) Segments [J].

Barbié, V ;

Lefranc, MP .

EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, 1998, 15 (03) :171-183

[3] GenBank [J].

Benson, DA ;

Karsch-Mizrachi, I ;

Lipman, DJ ;

Ostell, J ;

Rapp, BA ;

Wheeler, DL .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :15-18

[4] Fusion gene transcripts and Ig/TCR gene rearrangements are complementary but infrequent targets for PCR-based detection of minimal residual disease in acute myeloid leukemia [J].

Boeckx, N ;

Willemse, MJ ;

Szczepanski, T ;

van der Velden, VHJ ;

Langerak, AW ;

Vandekerckhove, P ;

van Dongen, JJM .

LEUKEMIA, 2002, 16 (03) :368-375

[5] Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR [J].

Brüggemann, M ;

Droese, J ;

Bolz, I ;

Lüth, P ;

Pott, C ;

von Neuhoff, N ;

Scheuering, U ;

Kneba, M .

LEUKEMIA, 2000, 14 (08) :1419-1425

[6] CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS [J].

CHOTHIA, C ;

LESK, AM .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) :901-917

[7] Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy [J].

de Haas, V ;

Verhagen, OJHM ;

von dem Borne, AEGK ;

Kroes, W ;

van den Berg, H ;

van der Schoot, CE .

LEUKEMIA, 2001, 15 (01) :134-140

[8] Rapid, multifluorescent TCRG Vγ and Jγ typing:: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations [J].

Delabesse, E ;

Burtin, ML ;

Millien, C ;

Madonik, A ;

Arnulf, B ;

Beldjord, K ;

Valensi, F ;

Macintyre, EA .

LEUKEMIA, 2000, 14 (06) :1143-1152

[9] Potential of LightCycler technology for quantification of minimal residual disease in childhood acute lymphoblastic leukemia [J].

Eckert, C ;

Landt, O ;

Taube, T ;

Seeger, K ;

Beyermann, B ;

Proba, J ;

Henze, G .

LEUKEMIA, 2000, 14 (02) :316-323

[10] Protein displays of the human T cell receptor alpha, beta, gamma and delta variable and joining regions [J].

Folch, G ;

Scaviner, D ;

Contet, V ;

Lefranc, MP .

EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, 2000, 17 (04) :205-215

← 1 2 3 4 5 →