Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) increased MMP-9 activity in murine macrophage

被引：42

作者：

Lee, HS

Shin, HH

Kwon, BS

Choi, HS ^{[1
]}

机构：

[1] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea

[2] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2003年 / 88卷 / 05期

关键词：

GITR; MMP-9; murine macrophages;

D O I：

10.1002/jcb.10456

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucocorticoid induced tumor necrosis factor receptor (GITR), anew TNFR family, increased production of matrix matalloproteinase (MMP-9) in murine macrophages. Murine macrophages produced a band of gelatinolytic activity at 100 kDa when stimulated for 18 h with soluble GITR. MMP-9 was identified by gelatin zymography and Western blot. Previous results demonstrated that murine macrophages express GITR and GITR ligand constitutively. Induction of MMP-9 was synergistic with co-treatment of INF-gamma. MMPs could play a critical role in progression and promotion of tissue injury after inflammation stimulated by GITR/ligand system. (C) 2003 Wiley-Liss, Inc.

引用

页码：1048 / 1056

页数：9

共 42 条

[1] 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB [J].