Nonparametric survival estimation when death is reported with delay

被引:9
作者
Hubbard, AE [1 ]
Van Der Laan, MJ
Enanoria, W
Colford, JM
机构
[1] Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Sch Publ Hlth, Div Publ Hlth Biol & Epidemiol, Berkeley, CA 94720 USA
关键词
right-censored data; reporting delays; influence curve; Kaplan-Meier estimator;
D O I
10.1023/A:1009689625311
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
In disease registries there can be a delay between death of a subject and the reporting of this death to the data analyst. If researchers use the Kaplan-Meier estimator and implicitly assumed that subjects who have yet to have death reported are still alive, i.e. are censored at the time of analysis, the Kaplan-Meier estimator is typically inconsistent. Assuming censoring is independent of failure, we provide a simple estimator that is consistent and asymptotically efficient. We also provide estimates of the asymptotic variance of our estimator and simulations that demonstrate the favorable performance of these estimators. Finally, we demonstrate our methods by analyzing AIDS survival data. This analysis underscores the pitfalls of not accounting for delay when estimating the survival distribution and suggests a significant reduction in bias by using our estimator.
引用
收藏
页码:237 / 250
页数:14
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