Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease - A magnetic resonance imaging analysis

被引:165
作者
Hampel, H
Teipel, SJ
Alexander, GE
Horwitz, B
Teichberg, D
Schapiro, MB
Rapoport, SI
机构
[1] Univ Munich, Sch Med, Dept Psychiat, Geriatr Psychiat Branch, D-80336 Munich, Germany
[2] NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1001/archneur.55.2.193
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Pathological studies in Alzheimer disease indicate the specific loss of layer III and V large pyramidal neurons in association cortex. These neurons give rise to long corticocortical connections within and between the cerebral hemispheres. Objective: To evaluate the corpus callosum as an in vivo marker for cortical neuronal loss. Method: Using a new imaging technique, we measured region-specific corpus callosum atrophy in patients with Alzheimer disease and correlated the changes with neuropsychological functioning. Total cross-sectional area of the corpus callosum and areas of 5 callosal subregions were measured on midsagittal magnetic resonance imaging scans of 14 patients with Alzheimer disease (mean age, 64.4 years; Mini-Mental State Examination score, 11.4) and 22 healthy age-and sex-matched control subjects (mean age, 66.6 years; Mini-Mental State Examination score, 29.8). All subjects had minimal white matter changes. Results: The total callosal area was significantly reduced in the patients with Alzheimer disease, with the greatest changes in the rostrum and splenium and relative sparing of the callosal body. Regional callosal atrophy correlated significantly with cognitive impairment in the patients with Alzheimer disease, but not with age or the white matter hyperintensities score. Conclusions: Callosal atrophy in patients with Alzheimer disease with only minimal white matter changes may indicate loss of callosal efferent neurons in corresponding regions of the cortex. Because these neurons are a subset of corticocortical projecting neurons, region-specific callosal atrophy may serve as a marker of progressive neocortical disconnection in Alzheimer disease.
引用
收藏
页码:193 / 198
页数:6
相关论文
共 41 条
[1]   The spatial pattern of discrete beta-amyloid deposits in Alzheimer's disease reflects synaptic disconnection [J].
Armstrong, RA .
DEMENTIA, 1996, 7 (02) :86-90
[2]   INCIDENTAL SUBCORTICAL LESIONS IDENTIFIED ON MAGNETIC-RESONANCE-IMAGING IN THE ELDERLY .2. POSTMORTEM PATHOLOGICAL CORRELATIONS [J].
AWAD, IA ;
JOHNSON, PC ;
SPETZLER, RF ;
HODAK, JA .
STROKE, 1986, 17 (06) :1090-1097
[3]   METHODS AND THEORY OF RELIABILITY [J].
BARTKO, JJ ;
CARPENTER, WT .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 1976, 163 (05) :307-317
[4]   HUMAN CORPUS-CALLOSUM IN AGING AND ALZHEIMERS-DISEASE - A MAGNETIC-RESONANCE-IMAGING STUDY [J].
BIEGON, A ;
EBERLING, JL ;
RICHARDSON, BC ;
ROOS, MS ;
WONG, STS ;
REED, BR ;
JAGUST, WJ .
NEUROBIOLOGY OF AGING, 1994, 15 (04) :393-397
[5]   BRAIN MR - PATHOLOGIC CORRELATION WITH GROSS AND HISTOPATHOLOGY .1. LACUNAR INFARCTION AND VIRCHOW-ROBIN SPACES [J].
BRAFFMAN, BH ;
ZIMMERMAN, RA ;
TROJANOWSKI, JQ ;
GONATAS, NK ;
HICKEY, WF ;
SCHLAEPFER, WW .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1988, 151 (03) :551-558
[6]   BRAIN MR - PATHOLOGIC CORRELATION WITH GROSS AND HISTOPATHOLOGY .2. HYPERINTENSE WHITE-MATTER FOCI IN THE ELDERLY [J].
BRAFFMAN, BH ;
ZIMMERMAN, RA ;
TROJANOWSKI, JQ ;
GONATAS, NK ;
HICKEY, WF ;
SCHLAEPFER, WW .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1988, 151 (03) :559-566
[7]   THE NEUROTRANSMITTERS AND POSTSYNAPTIC ACTIONS OF CALLOSALLY PROJECTING NEURONS [J].
CONTI, F ;
MANZONI, T .
BEHAVIOURAL BRAIN RESEARCH, 1994, 64 (1-2) :37-53
[8]   AMYGDALA ATROPHY IN ALZHEIMERS-DISEASE - AN IN-VIVO MAGNETIC-RESONANCE-IMAGING STUDY [J].
CUENOD, CA ;
DENYS, A ;
MICHOT, JL ;
JEHENSON, P ;
FORETTE, F ;
KAPLAN, D ;
SYROTA, A ;
BOLLER, F .
ARCHIVES OF NEUROLOGY, 1993, 50 (09) :941-945
[9]   TOPOGRAPHY OF THE HUMAN CORPUS-CALLOSUM [J].
DELACOSTE, MC ;
KIRKPATRICK, JB ;
ROSS, ED .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1985, 44 (06) :578-591
[10]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198