Phosphoramidite solid-phase synthesis of site-specifically glycosylated oligodeoxynucleotides

被引：21

作者：

Matsuura, K

Hibino, M

Kataoka, M

Hayakawa, Y

Kobayashi, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Nagoya Univ, Grad Sch Human Informat, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期

关键词：

carbohydrate; oligodeoxynucleotide; solid-phase synthesis;

D O I：

10.1016/S0040-4039(00)01292-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A galactose-modified deoxyuridine phosphoramidite was synthesized via the Heck reaction and applied to solid-phase synthesis to provide a new type of oligo DNA-galactose conjugates, which maintained stringent base-pairing fidelity for unique DNA sequences. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7529 / 7533

页数：5

共 16 条

[1] Conjugation of plasmid DNAs with lactose via diazocoupling enhances resistance to restriction enzymes and acquires binding affinity to galactose-specific lectin [J].