The Bcg host-resistance gene

被引：18

作者：

Buu, N ^{[1
]}

Sánchez, F ^{[1
]}

Schurr, E ^{[1
]}

机构：

[1] Montreal Gen Hosp, Res Inst, McGill Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2000年 / 31卷

关键词：

D O I：

10.1086/314067

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Beg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.

引用

页码：S81 / S85

页数：5

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