First total synthesis of a GPI-anchored peptide

被引：41

作者：

Xue, J ^{[1
]}

Shao, N ^{[1
]}

Guo, ZW ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 10期

关键词：

D O I：

10.1021/jo034213t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A GPI-anchored dipeptide of sperm CD52 antigen was prepared through a convergent synthesis. First, the dipeptide with its C-terminus free and the GPI with its nonreducing end phosphoethanolamine bearing a free amino group were synthesized separately. Then, the two building blocks were coupled with use of EDC/HOBt as the condensation reagent. Finally, the GPI-anchored peptide was deprotected to give the target molecule 1.

引用

页码：4020 / 4029

页数：10

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