Gene silencing - a new theory of aging

被引：22

作者：

Burzynski, SR ^{[1
]}

机构：

[1] Burzynski Clin, Houston, TX 77055 USA

来源：

MEDICAL HYPOTHESES | 2003年 / 60卷 / 04期

关键词：

D O I：

10.1016/S0306-9877(03)00050-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aging process involves silencing of the genes through methylation of promoter sequences and the acetylation of histones. This process contributes not only to aging, but also cancer when silencing affects tumor suppressor genes. Antineoplastons work as molecular switches, turning inactive tumor suppressor genes back on through demethylation of the DNA and acetylation of the histones. While they activate tumor suppressor genes, antineoplastons also activate some additional genes silenced during the aging process. Evidence of activation of silenced genes can be pursued by documenting the relationship between 'molecular switches' DNA-demethylating agents and histone deacetylation inhibitors, genes which are turned on by them, and clinical anti-aging changes. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：578 / 583

页数：6

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