Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes

被引:22
作者
Bragg, Jason G.
Wagner, Andreas [1 ]
机构
[1] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland
[2] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA
关键词
elemental composition; proteome; evolution;
D O I
10.1098/rspb.2006.0290
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Natural selection can influence even the lowest level of biological organization, the atomic composition of biological macromolecules. In analysing genome-scale gene expression data, we find that ancestral yeast strains preferentially express proteins with low carbon content during carbon limitation, relative to strains selected in the laboratory under carbon limitation. The likely reason is that the artificially selected strains acquire adaptations that refine their response to the limitation or partly circumvent the limiting condition. This finding extends previous work which shows that natural selection can act on the atomic costs of proteins. We also show that genes with high carbon and nitrogen content are less likely to have duplicates, indicating that atomic composition also plays a role in evolution by gene duplication. Taken together, our results contribute to the emerging view that protein atomic composition influences genome and transcriptome evolution.
引用
收藏
页码:1063 / 1070
页数:8
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