Circulating 25-Hydroxyvitamin D and the Risk of Rarer Cancers: Design and Methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

被引：63

作者：

Gallicchio, Lisa ^{[1
,2
]}

Helzlsouer, Kathy J. ^{[1
,2
]}

Chow, Wong-Ho ^{[3
]}

Freedman, D. Michal ^{[3
]}

Hankinson, Susan E. ^{[4
,5
,6
]}

Hartge, Patricia ^{[3
]}

Hartmuller, Virginia ^{[7
]}

Harvey, Chinonye ^{[8
]}

Hayes, Richard B. ^{[9
,10
]}

Horst, Ronald L. ^{[11
]}

Koenig, Karen L. ^{[10
]}

Kolonel, Laurence N. ^{[12
]}

Laden, Francine ^{[4
,5
,6
,13
]}

McCullough, Marjorie L. ^{[14
]}

Parisi, Dominick ^{[15
]}

Purdue, Mark P. ^{[3
]}

Shu, Xiao-Ou ^{[16
]}

Snyder, Kirk ^{[15
]}

Stolzenberg-Solomon, Rachael Z. ^{[3
]}

Tworoger, Shelley S. ^{[4
,5
]}

Varanasi, Arti ^{[17
]}

Virtamo, Jarmo ^{[18
]}

Wilkens, Lynne R. ^{[12
]}

Xiang, Yong-Bing ^{[19
]}

Yu, Kai ^{[3
]}

Zeleniuch-Jacquotte, Anne ^{[9
,10
]}

Zheng, Wei ^{[16
]}

Abnet, Christian C. ^{[3
]}

Albanes, Demetrius ^{[3
]}

Bertrand, Kimberly ^{[6
]}

Weinstein, Stephanie J. ^{[3
]}

机构：

[1] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD 21202 USA

[2] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[3] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[4] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[7] Sci Consulting Grp Inc, Gaithersburg, MD USA

[8] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[9] NYU, Inst Canc, New York, NY USA

[10] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[11] Heartland Assays Inc, Ames, IA USA

[12] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[13] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[14] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[15] Informat Management Serv Inc, Silver Spring, MD USA

[16] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, Nashville, TN 37212 USA

[17] Westat Corp, Rockville, MD USA

[18] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[19] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

case-control studies; cohort studies; methods; neoplasms; prospective studies; vitamin D; BASE-LINE CHARACTERISTICS; PROSTATE-CANCER; BREAST-CANCER; SERUM; 25-HYDROXYVITAMIN-D; POSTMENOPAUSAL WOMEN; MORTALITY-RATES; OVARIAN-CANCER; MALE SMOKERS; D DEFICIENCY; US WOMEN;

D O I：

10.1093/aje/kwq116

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-< 75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.

引用

页码：10 / 20

页数：11

共 52 条

[1]

[Anonymous], N ENGL J MED

[2]

[Anonymous], 1994, Ann Epidemiol, V4, P1

[3]

[Anonymous], AHRQ PUBLICATION

[4]

Antoniucci DM, 2005, CLIN CHEM, V51, P258

[5] The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics [J].

Calle, EE ;

Rodriguez, C ;

Jacobs, EJ ;

Almon, ML ;

Chao, A ;

McCullough, ML ;

Feigelson, HS ;

Thun, MJ .

CANCER, 2002, 94 (09) :2490-2501

[6] Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers [J].

Chen, W. ;

Dawsey, S. M. ;

Qiao, Y-L ;

Mark, S. D. ;

Dong, Z-W ;

Taylor, P. R. ;

Zhao, P. ;

Abnet, C. C. .

BRITISH JOURNAL OF CANCER, 2007, 97 (01) :123-128

[7]

Cleveland W.S., 1992, Statistical Models in S, P309, DOI DOI 10.1201/9780203738535-8

[8] The Nurses' Health Study: Lifestyle and health among women [J].

Colditz, GA ;

Hankinson, SE .

NATURE REVIEWS CANCER, 2005, 5 (05) :388-396

[9] Vitamin D, calcium, and breast cancer risk: A review [J].

Cui, Yan ;

Rohan, Thomas E. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (08) :1427-1437

[10] Vitamin D and cancer: Current dilemmas and future needs [J].

Davis, Cindy D. ;

Hartmuller, Virginia ;

Freedman, D. Michal ;

Hartge, Patricia ;

Picciano, Mary Frances ;

Swanson, Christine A. ;

Milner, John. A. .

NUTRITION REVIEWS, 2007, 65 (08) :S71-S74

← 1 2 3 4 5 6 →