Why polyps regenerate and we don't:: Towards a cellular and molecular framework for Hydra regeneration

被引：137

作者：

Bosch, Thomas C. G. ^{[1
]}

机构：

[1] Univ Kiel, Inst Zool, D-24098 Kiel, Germany

来源：

DEVELOPMENTAL BIOLOGY | 2007年 / 303卷 / 02期

关键词：

regeneration; stem cells; epithelium; peptides; Cnidaria; hydra;

D O I：

10.1016/j.ydbio.2006.12.012

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basis for Hydra's enormous regeneration capacity is the "stem cellness" of its epithelium which continuously undergoes self-renewing mitotic divisions and also has the option to follow differentiation pathways. Now, emerging molecular tools have shed light on the molecular processes controlling these pathways. In this review I discuss how the modular tissue architecture may allow continuous replacement of cells in Hydra. I also describe the discovery and regulation of factors controlling the transition from self-renewing epithelial stem cells to differentiated cells. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：421 / 433

页数：13

共 119 条

[1] Regeneration and gene regulation in planarians [J].