Cellular microbiology of intracellular Salmonella enterica:: functions of the type III secretion system encoded by Salmonella pathogenicity island 2

被引：119

作者：

Kuhle, V ^{[1
]}

Hensel, M ^{[1
]}

机构：

[1] FAU Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 22期

关键词：

Salmonella; intracellular pathogen; type III secretion system; SPI2;

D O I：

10.1007/s00018-004-4248-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The facultative intracellular pathogen Salmonella enterica resides in a special membrane compartment of the host cell and modifies its host to achieve intracellular survival and proliferation. The type III secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has a central role in the interference of intracellular Salmonella with host cell functions. SPI2 function affects antimicrobial defense mechanisms of the host, intracellular transport processes, integrity and function of the cytoskeleton and host cell death. These modifications are mediated by translocation of a large number of effector proteins by the SPI2 system. In this review, we summarize recent work on the cellular phenotypes related to SPI2 function and contribution of SPI2 effector proteins to these manipulations. These studies reveal a complex set of pathogenic interferences between intracellular Salmonella and its host cells.

引用

页码：2812 / 2826

页数：15

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