CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease

被引：36

作者：

Smith, PD ^{[1
]}

O'Hare, MJ ^{[1
]}

Park, DS ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Neurosci Grp, Ottawa, ON K1H 8M5, Canada

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1016/j.molmed.2004.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclin-dependent kinases (CDKs) are best characterized for their ability to control cell-cycle progression. However, CDK family members are now known to regulate biological processes outside of the cell cycle, including transcription and neuronal development. Multiple CDKs (both cell cycle and non-cell-cycle related) have been associated with neurological conditions, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This review will explore the emerging evidence supporting a role for CDKs in neuronal death, focusing on mechanisms involved in the dopaminergic neurodegeneration of PD. An improved understanding of CDK involvement in cell death signaling could facilitate the development of innovative strategies to halt or slow down the characteristic death processes that are associated with some neurodegenerative conditions.

引用

页码：445 / 451

页数：7

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