Gene networks

被引：28

作者：

Kolchanov, NA ^{[1
]}

Anan'ko, EA ^{[1
]}

Kolpakov, FA ^{[1
]}

Podkolodnaya, OA ^{[1
]}

Ignat'eva, EV ^{[1
]}

Goryachkovskaya, TN ^{[1
]}

Stepanenko, IL ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

来源：

MOLECULAR BIOLOGY | 2000年 / 34卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

genes; expression regulation; gene networks; databases; signal transduction pathways;

D O I：

10.1007/BF02759554

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene network is a group of genes functioning in a coordinated manner to control vital processes in an organism. Each gene network includes several essential components: (1) a group of genes which form a core of a gene network, (2) proteins encoded by these genes, (3) signal transduction pathways, (4) negative and positive feedback which provide for autoregulation, and (5) low-molecular-weight compounds. To accumulate the information on gene networks, a database GeneNet has been developed (http://wwwmgs.bionet.nsc.ru/systems/mgl/genenet/). At present, GeneNet contains the data on 16 gene networks which are arranged in six sections according to the subject concerned: lipid metabolism, steroidogenesis, erythropoiesis, antiviral response, plant seed development, and heat shock. Analysis of these data revealed the following principles of the gene network organization: (1) there is a great variety of molecular mechanisms which provide for a feedback regulation; (2) each gene network includes key genes which coordinate the function of the other genes of the gene network; (3) one transcription factor activates many genes via a cassette mechanism; and (4) gene networks are autoregulated via regulatory circuits with positive and negative feedback.

引用

页码：449 / 460

页数：12

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