New generation dopaminergic agents.: 2.: Discovery of 3-OH-phenoxyethnamine and 3-OH-N1-phenylpiperazine dopaminergic templates

被引：19

作者：

Mewshaw, RE

Husbands, M

Gildersleeve, ES

Webb, MB

Shi, XJ

Mazandarani, H

Cockett, MI

Ochalski, R

Brennan, JA

Abou-Gharbia, M

Marquis, K

McGaughey, GB

Coupet, J

Andree, TH

机构：

[1] Wyeth Ayerst Res Labs, Dept Global Chem Sci, Princeton, NJ 08543 USA

[2] Wyeth Ayerst Res Labs, CNS Disorders Dept, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(98)00014-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Described in this report is a systematic study which led to the identification of two new dopamine D-2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D-2 partial agonists as well as templates for the future design of novel dopaminergic agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：295 / 300

页数：6

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