Pathways for protein folding: is a new view needed?

被引：231

作者：

Pande, VS ^{[1
]}

Grosberg, AY

Tanaka, T

Rokhsar, DS

机构：

[1] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[2] MIT, Dept Phys, Cambridge, MA 02139 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Sci, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(98)80012-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Theoretical studies using simplified models of proteins have shed light on the general heteropolymeric aspects of the folding problem. Recent work has emphasized the statistical aspects of folding pathways. In particular, progress has been made in characterizing the ensemble of transition state conformations and elucidating the role of intermediates. These advances suggest a reconciliation between the new ensemble approaches and the classical view of a folding pathway.

引用

页码：68 / 79

页数：12

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