Medaka dmY/dmrt1Y is not the universal primary sex-determining gene in fish

被引：72

作者：

Volff, JN ^{[1
]}

Kondo, M ^{[1
]}

Schartl, M ^{[1
]}

机构：

[1] Univ Wurzburg, Biozentrum, D-97074 Wurzburg, Germany

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(03)00051-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An outstanding candidate for a primary male-determining gene equivalent to Sry of mammals has been recently described from a non-mammalian vertebrate, the medaka fish (Oryzias latipes). However, the universality of dmY/dmrt1Y as the master sex-determining gene in fish is questionable. Phylogenetic analysis shows that dmY/dmrt1Y is an evolutionarily young Y chromosome-specific duplicate of a gene involved in testis development in vertebrates, and that this duplicate cannot be the primary sex-determining gene in most other fish species. Study of alternative fish models will probably uncover new genetic strategies controlling sexual dimorphism in vertebrates.

引用

页码：196 / 199

页数：4

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