Mechanisms of occupational asthma induced by isocyanates

被引:22
作者
Deschamps, F
Prevost, A
Lavaud, F
Kochman, S
机构
[1] Hop Maison Blanche, Dept Occupat Dis, F-51092 Reims, France
[2] Inst Jean Godinoi, F-51056 Reims, France
[3] Hop Maison Blanche, Dept Resp & Allerg Dis, F-51092 Reims, France
关键词
D O I
10.1016/S0003-4878(97)00047-1
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Isocyanates are some of the most important low molecular weight chemicals associated with occupational asthma, These compounds are often volatile and they are highly reactive on mucous membranes, especially the conjunctivae and respiratory tract. Despite numerous data derived from experimental and clinical investigations, there is no agreement concerning the real mechanisms involved in isocyanate-induced occupational asthma, In fact, the cause of occupational asthma is multifactorial. The aim of this paper is to review the involved physiological causes of isocyanate-induced asthma; the main mechanisms are immunological, pharmacological and/or irritative. (C) 1998 British Occupational Hygiene Society. Published by Elsevier Science Ltd.
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页码:33 / 36
页数:4
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