Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP

被引：122

作者：

Balaban, Naomi

Cirioni, Oscar

Giacometti, Andrea

Ghiselli, Roberto

Braunstein, Joel B.

Silvestri, Carmela

Mocchegiani, Federico

Saba, Vittorio

Scalise, Giorgio

机构：

[1] Tufts Univ, Dept Biomed Sci, Cummings Sch Vet Med, Div Infect Dis, North Grafton, MA 01536 USA

[2] Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy

[3] Univ Ancona, Dept Gen Surg, INRCA, IRRCS, Ancona, Italy

[4] Centegen Inc, Baltimore, MD 21208 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.01097-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

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收藏

页码：2226 / 2229

页数：4

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