The molecular choreography of a store-operated calcium channel

被引：417

作者：

Lewis, Richard S. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA

来源：

NATURE | 2007年 / 446卷 / 7133期

关键词：

D O I：

10.1038/nature05637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

引用

页码：284 / 287

页数：4

共 42 条

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