Asymmetric versus C2-symmetric ligands:: Origin of the enantioselectivity in ruthenium-pybox-catalyzed cyclopropanation reactions

被引：25

作者：

Cornejo, A

Fraile, JM

García, JI

Gil, MJ

Martínez-Merino, V

Mayoral, JA

Salvatella, L

机构：

[1] Univ Zaragoza, CSIC, Inst Ciencia Mat Aragon, E-50009 Zaragoza, Spain

[2] Univ Zaragoza, CSIC, Inst Catalisis Homogenea, E-50009 Zaragoza, Spain

[3] Univ Publ Navarra, Dept Quim Aplicada, Pamplona 31006, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

asymmetric catalysis; density functional calculations; enantioselectivity; N ligands; ruthenium;

D O I：

10.1002/anie.200461418

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) One stereogenic center suffices in pyridinebis(oxazoline) (pybox) ligands for efficient ruthenium-catalyzed cyclopropanation. A molecular-modeling study reveals the main origin of the enantioselectivity to be unfavorable steric interactions between the substituent on pybox and styrene in a Si approach to the carbene intermediate (see picture).

引用

页码：458 / 461

页数：4

共 18 条

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[Anonymous], ANGEW CHEM

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