Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders

被引：47

作者：

Onore, Charity ^{[1
,2
]}

Enstrom, Amanda ^{[1
,2
]}

Krakowiak, Paula ^{[2
,3
]}

Hertz-Picciotto, Irva ^{[2
,3
]}

Hansen, Robin ^{[2
,4
]}

Van de Water, Judy ^{[2
,5
]}

Ashwood, Paul ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

[2] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA

[3] Univ Calif Davis, Div Epidemiol, Dept Publ Hlth Sci, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA

[5] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 216卷 / 1-2期

关键词：

Autism spectrum disorders; Inflammation; IL-17; IL-23; Lymphocytes; T(H)17 cells; PERIPHERAL-BLOOD; ACTIVATION; CELLS; INTERLEUKIN-17; NEUROGENESIS; PROMOTES; BETA;

D O I：

10.1016/j.jneuroim.2009.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：126 / 129

页数：4

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