Vaccine-Associated Herpes Zoster Opthalmicus and Encephalitis in an Immunocompetent Child

被引：38

作者：

Chouliaras, Giorgos ^{[1
]}

Spoulou, Vana ^{[1
]}

Quinlivan, Mark ^{[2
]}

Breuer, Judith ^{[2
]}

Theodoridou, Maria ^{[1
]}

机构：

[1] Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Athens, Greece

[2] UCL, Windeyer Inst, Dept Infect, London, England

来源：

PEDIATRICS | 2010年 / 125卷 / 04期

关键词：

varicella-zoster virus; vaccine; Oka strain; herpes zoster; encephalitis; VARICELLA VACCINE; UNITED-STATES; OKA VACCINE; VIRUS; INFECTION; STRAIN; GENOTYPES; PATIENT; SYSTEM;

D O I：

10.1542/peds.2009-2633

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Varicella-zoster virus vaccine has diminished the consequences of chicken pox in terms of health and economical burden. The increasing number of doses administered worldwide has revealed rare but important adverse effects that had not occurred during clinical trials. We report here the case of an immunocompetent 31/2-year-old girl who developed encephalitis and herpes zoster opthalmicus 20 months after her immunization with varicella-zoster virus vaccine. Molecular analysis confirmed the vaccine strain as the causative agent. After an intravenous course with acyclovir, the child made a full recovery with no neurologic sequelae. Pediatrics 2010; 125: e969-e972

引用

页码：E969 / E972

页数：4

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