Replacing stavudine by abacavir reduces lactate levels and may improve lipoatrophy

被引：15

作者：

García-Benayas, T

Blanco, F

de la Cruz, JJ

Soriano, V

González-Lahoz, J

机构：

[1] Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain

[2] Univ Autonoma Madrid, Dept Prevent Med & Publ Hlth, Madrid, Spain

来源：

AIDS | 2003年 / 17卷 / 06期

关键词：

D O I：

10.1097/00002030-200304110-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stavudine has been associated with lipoatrophy and hyperlactatemia, and its removal might improve morphological and metabolic changes. In a prospective case-control study, serum lactate levels and lipoatrophy were examined after replacing stavudine by abacavir in patients on successful antiretroviral therapy. This intervention was safe and provided significant reductions in lactate levels over 6 and 12 months. A trend towards an improvement of lipoatrophy was also noted.

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收藏

页码：921 / 924

页数：4

相关论文

共 15 条

[1]

BLANCO F, 2001, AIDS REV, V3, P98

[2] Lactacidemia in asymptomatic HIV-infected subjects receiving nucleoside reverse-transcriptase inhibitors [J].

Boffito, M ;

Marietti, G ;

Audagnotto, S ;

Raiter, R ;

Di Perri, G .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (04) :558-559

[3] Hyperlactatemia and antiretroviral therapy: The Swiss HIV Cohort Study [J].

Boubaker, K ;

Flepp, M ;

Sudre, P ;

Furrer, H ;

Haensel, A ;

Hirschel, B ;

Boggian, K ;

Chave, JP ;

Bernasconi, E ;

Egger, M ;

Opravil, M ;

Rickenbach, M ;

Francioli, P ;

Telenti, A .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (11) :1931-1937

[4] Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].

Brinkman, K ;

Smeitink, JA ;

Romijn, JA ;

Reiss, P .

LANCET, 1999, 354 (9184) :1112-1115

[5] Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy - A randomized trial [J].

Carr, A ;

Workman, C ;

Smith, DE ;

Hoy, J ;

Hudson, J ;

Doong, N ;

Martin, A ;

Amin, J ;

Freund, J ;

Law, M ;

Cooper, DA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (02) :207-215

[6] Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance [J].

Carr, A ;

Samaras, K ;

Chisholm, DJ ;

Cooper, DA .

LANCET, 1998, 351 (9119) :1881-1883

[7]

Galli M, 2002, J ACQ IMMUN DEF SYND, V29, P21, DOI 10.1097/00126334-200201010-00003

[8] Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy [J].

John, M ;

Moore, CB ;

James, IR ;

Nolan, D ;

Upton, RP ;

McKinnon, EJ ;

Mallal, SA .

AIDS, 2001, 15 (06) :717-723

[9]

JOHN M, 2002, 9 C RETR OPP INF SEA

[10]

MCCOMSEY G, 2002, 9 C RETR OPP INF SEA