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Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry

被引：26
作者：
Engler, M
Rüsing, G
Sörgel, F
Holzgrabe, U
机构：
[1] Univ Bonn, Inst Pharmazeut, D-53115 Bonn, Germany
[2] Inst Biomed & Pharmaceut Res, D-90562 Nurnberg, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期
关键词：
D O I：
10.1128/AAC.42.5.1151
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8-desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl ring. Thus, photodefluorination of quinolone antibacterial agents is found and proved for the first time by LC-MS/MS.
引用
收藏
页码：1151 / 1159
页数：9
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