N1-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging:: cyclization to a cinnolinone prevents formation of unstable nitrosamines

被引:27
作者
Hardeland, R.
Backhaus, C.
Fadavi, A.
Hess, M.
机构
关键词
D O I
10.1111/j.1600-079X.2007.00431.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:104 / 105
页数:2
相关论文
共 8 条
[1]  
Acuña-Castroviejo D, 2003, ADV EXP MED BIOL, V527, P549
[2]   Mechanisms of NO release by N1-nitrosomelatonin:: Nucleophilic attack versus reducing pathways [J].
De Biase, PM ;
Turjanski, AG ;
Estrin, DA ;
Doctorovich, F .
JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (15) :5790-5798
[3]   Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice [J].
Escames, G ;
López, LC ;
Tapias, V ;
Utrilla, P ;
Reiter, RJ ;
Hitos, AB ;
León, J ;
Rodríguez, MI ;
Acuña-Castroviejo, D .
JOURNAL OF PINEAL RESEARCH, 2006, 40 (01) :71-78
[4]   AN INVESTIGATION OF THE METABOLISM OF N-NITROSO-N-METHYLANILINE BY PHENOBARBITAL-INDUCED AND PYRAZOLE-INDUCED SPRAGUE-DAWLEY RAT-LIVER AND ESOPHAGUS DERIVED S-9 [J].
GOLD, B ;
FARBER, J ;
ROGAN, E .
CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 61 (03) :215-228
[5]   Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts [J].
Gonçalves, LL ;
Beland, FA ;
Marques, MM .
CHEMICAL RESEARCH IN TOXICOLOGY, 2001, 14 (02) :165-174
[6]   Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species:: Formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK [J].
Guenther, AL ;
Schmidt, SI ;
Laatsch, H ;
Fotso, S ;
Ness, H ;
Ressmeyer, AR ;
Poeggeler, B ;
Hardeland, R .
JOURNAL OF PINEAL RESEARCH, 2005, 39 (03) :251-260
[7]   QSAR modeling based on structure-information for properties of interest in human health [J].
Hall, LH ;
Hall, LM .
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2005, 16 (1-2) :13-41
[8]   DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice [J].
Skipper, Paul L. ;
Trudel, Laura J. ;
Kensler, Thomas W. ;
Groopman, John D. ;
Egner, Patricia A. ;
Liberman, Rosa G. ;
Wogan, Gerald N. ;
Tannenbaum, Steven R. .
CHEMICAL RESEARCH IN TOXICOLOGY, 2006, 19 (08) :1086-1090