NALPs: A novel protein family involved in inflammation

被引：567

作者：

Tschopp, J ^{[1
]}

Martinon, F ^{[1
]}

Burns, K ^{[1
]}

机构：

[1] Univ Lausanne, Inst Biochem, BIL, Biomed Res Ctr, CH-1066 Epalinges, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrm1019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A newly discovered family of cytoplasmic proteins-the NALPs-has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.

引用

页码：95 / 104

页数：10

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