Interactions between amphotericin B and nitroimidazoles against Candida albicans

被引：11

作者：

Cury, AE ^{[1
]}

Hirschfeld, MPM ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 Sao Paulo, SP, Brazil

来源：

MYCOSES | 1997年 / 40卷 / 5-6期

关键词：

Candida albicans; antifungal drug combinations; amphotericin B; nitroimidazoles;

D O I：

10.1111/j.1439-0507.1997.tb00212.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

This work proved that nitroimidazole antiprotozoal agents, such as metronidazole, ornidazole, secnidazole and tinidazole, in concentrations of up to 64 mu g ml(-1) did not present any antifungal activity against 17 strains of Candida albicans. The combination of each drug with amphotericin B showed the occurrence of variable interactions according to the studied strain. Promising results were observed based on synergistic and additive interactions of the polyene with the metronidazole; the inhibitory and lethal activities of the drugs were potentiated against all strains in concentrations reachable in vivo.

引用

页码：187 / 192

页数：6

共 37 条

[1]

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[2]

METHOD FOR TESTING FOR SYNERGY WITH ANY NUMBER OF AGENTS [J].