Quantitative characterization of mixing of dry powders in V-blenders

被引:93
作者
Brone, D [1 ]
Alexander, A [1 ]
Muzzio, FJ [1 ]
机构
[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08855 USA
关键词
D O I
10.1002/aic.690440206
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Experiments were conducted to determine the effect of rotation rate, fill level, and total number of revolutions on the mixing performance of a V-blender. The experiments were performed using 66-mu m red and green glass beads. Mixture uniformity was quantified after each experiment by infiltrating the mixtures with a binder, and using image analysis to examine slices of the solidified mixture. The mixing rate (as a function of total revolutions) was not affected by changing the rotation rate between 8 and 24 Ipm. The mixing rare increased significantly as the fill percentage was decreased from 60% to 40% of the total vessel volume. In a symmetric blender such as a V-blender, the rate of mixing is limited by the rate of mass transfer across the vessel plane of symmetry orthogonal to the mis of rotation. A one-parameter model based on the amount of material that crossed the plane of symmetry per revolution displayed good agreement with the experimental data.
引用
收藏
页码:271 / 278
页数:8
相关论文
共 35 条
[1]  
Adams J., 1956, T I CHEM ENG, V34, P91
[2]   BLEND UNIFORMITY AND UNIT DOSE SAMPLING [J].
BERMAN, J ;
PLANCHARD, JA .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1995, 21 (11) :1257-1283
[3]   Using flow perturbations to enhance mixing of dry powders in V-blenders [J].
Brone, D ;
Wightman, C ;
Connor, K ;
Alexander, A ;
Muzzio, FJ ;
Robinson, P .
POWDER TECHNOLOGY, 1997, 91 (03) :165-172
[4]   BLENDER GEOMETRY IN MIXING OF SOLIDS [J].
CAHN, DS ;
HEALY, TW ;
FUERSTEN.DW .
INDUSTRIAL & ENGINEERING CHEMISTRY PROCESS DESIGN AND DEVELOPMENT, 1965, 4 (03) :318-&
[5]   DIFFUSIONAL MECHANISM OF SOLID-SOLID MIXING [J].
CAHN, DS ;
FUERSTEN.DW ;
HEALY, TW ;
HOGG, R ;
ROSE, HE .
NATURE, 1966, 209 (5022) :494-&
[6]   THE MIXING OF SOLIDS IN TUMBLING MIXERS .2. [J].
CARLEYMACAULY, KW ;
DONALD, MB .
CHEMICAL ENGINEERING SCIENCE, 1964, 19 (03) :191-&
[7]   THE MIXING OF SOLIDS IN TUMBLING MIXERS .1. [J].
CARLEYMACAULY, KW ;
DONALD, MB .
CHEMICAL ENGINEERING SCIENCE, 1962, 17 (07) :493-&
[8]  
CARTENSEN JT, 1977, POWDER TECHNOL, V17, P273
[9]   A STUDY OF THE PERFORMANCE OF A MODIFIED V-SHAPED SOLIDS MIXER USING SEGREGATING MATERIALS [J].
CHANG, RK ;
CHANG, SI ;
ROBINSON, JR .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 80 (2-3) :171-178
[10]   A COMPARISON OF FREE-FLOWING, SEGREGATING AND NON-FREE-FLOWING, COHESIVE MIXING SYSTEMS IN ASSESSING THE PERFORMANCE OF A MODIFIED V-SHAPED SOLIDS MIXER [J].
CHANG, RK ;
BADAWY, S ;
HUSSAIN, MA ;
BUEHLER, JD .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1995, 21 (03) :361-368