Domains of rasGAP and rhoGAP are related

被引：17

作者：

Bax, B ^{[1
]}

机构：

[1] Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England

来源：

NATURE | 1998年 / 392卷 / 6675期

关键词：

D O I：

10.1038/33040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Guanine-nucleotide-binding (G) proteins are ‘switched off’ by the hydrolysis of their bound GTP. The GTP bound to the G protein Ras is hydrolysed intrinsically at a very slow rate1, so, in vivo, Ras is turned off by GTPase-activating proteins (GAPs). The structures of GTPase-activating domains (GAP domains), which usually occur as parts of larger proteins, indicate that the Ras and Rho families of small G proteins and their GAPs evolved in parallel.

引用

页码：447 / 448

页数：2

共 8 条

[1] Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
Ahmadian, MR
Stege, P
Scheffzek, K
Wittinghofer, A
[J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (09) : 686 - 689
[2] The structure of the GTPase-activating domain from p50rhoGAP
Barrett, T
Xiao, B
Dodson, EJ
Dodson, G
Ludbrook, SB
Nurmahomed, K
Gamblin, SJ
Musacchio, A
Smerdon, SJ
Eccleston, JF
[J]. NATURE, 1997, 385 (6615) : 458 - 461
[3] MUSSACHIO A, 1996, P NATL ACAD SCI USA, V93, P14373
[4] Structure at 1.65 angstrom of RhoA and its GTPase-activating protein in complex with a transition-state analogue
Rittinger, K
Walker, PA
Eccleston, JF
Smerdon, SJ
Gamblin, SJ
[J]. NATURE, 1997, 389 (6652) : 758 - 762
[5] DEFINITION OF GENERAL TOPOLOGICAL EQUIVALENCE IN PROTEIN STRUCTURES - A PROCEDURE INVOLVING COMPARISON OF PROPERTIES AND RELATIONSHIPS THROUGH SIMULATED ANNEALING AND DYNAMIC-PROGRAMMING
SALI, A
BLUNDELL, TL
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 212 (02) : 403 - 428
[6] The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
Scheffzek, K
Ahmadian, MR
Kabsch, W
Wiesmuller, L
Lautwein, A
Schmitz, F
Wittinghofer, A
[J]. SCIENCE, 1997, 277 (5324) : 333 - 338
[7] Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras
Scheffzek, K
Lautwein, A
Kabsch, W
Ahmadian, MR
Wittinghofer, A
[J]. NATURE, 1996, 384 (6609) : 591 - 596
[8] A VARIABLE GAP PENALTY-FUNCTION AND FEATURE WEIGHTS FOR PROTEIN 3-D STRUCTURE COMPARISONS
ZHU, ZY
SALI, A
BLUNDELL, TL
[J]. PROTEIN ENGINEERING, 1992, 5 (01): : 43 - 51

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