Determination of aromatic amine mutagens, PBTA-1 and PBTA-2, in river water by solid-phase extraction followed by liquid chromatography-tandem mass spectrometry

被引：11

作者：

Moriwaki, H

Harino, H

Hashimoto, H

Arakawa, R

Ohe, T

Yoshikura, T

机构：

[1] Osaka City Inst Publ Hlth & Environm Sci, Tennoji Ku, Osaka 5430026, Japan

[2] Kansai Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5648680, Japan

[3] Kyoto Womens Univ, Dept Food & Nutr, Higashiyama Ku, Kyoto 6058501, Japan

来源：

JOURNAL OF CHROMATOGRAPHY A | 2003年 / 995卷 / 1-2期

关键词：

water analysis; solid-phase extraction; aromatic amines;

D O I：

10.1016/S0021-9673(03)00514-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We describe a novel method for the determination of two kinds of aromatic amine mutagens, 2-[2-(acetylamino)-4-[bis(2-methoxyethyl)-amino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-1) and 2-[2-(acetylamino)-4-[bis(2-cyanoethyl)ethylamino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-2), in river water based on liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS). A solid-phase extraction procedure was used for the extraction of PBTA-1 and PBTA-2 from river water. The procedure was rapid and the relative standard deviations were below 4%. The detection limits of PBTA-1 and PBTA-2 in river water using the proposed method were found to be 1 and 2 ng/l, respectively. The compounds were detected by this method in river water taken from two sites in the Yodo River system at the ng/l level. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：239 / 243

页数：5

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