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EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein

被引：64
作者：
Callebaut, I
Mignotte, V
Souchet, M
Mornon, JP
机构：
[1] Univ Paris 06, CNRS UMR7590, LMCP, F-75252 Paris 05, France
[2] Univ Paris 07, CNRS UMR7590, LMCP, F-75252 Paris 05, France
[3] Inst Cochin Genet Mol, CNRS UMR8104, INSERM U567, Dept Hematol, F-91030 Paris, France
[4] CRG, Genset, F-91030 Evry, France
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 300卷 / 03期
基金：
澳大利亚研究理事会;
关键词：
phagocytosis; apoptosis; extracellular module; beta ig-h3; fibrillin; PSI-BLAST; hydrophobic cluster analysis;
D O I：
10.1016/S0006-291X(02)02904-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered. (C) 2002 Elsevier Science (USA). All rights reserved.
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收藏
页码：619 / 623
页数：5
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