Paraflagellar rod is vital for trypanosome motility

被引：164

作者：

Bastin, P ^{[1
]}

Sherwin, T ^{[1
]}

Gull, K ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

NATURE | 1998年 / 391卷 / 6667期

关键词：

D O I：

10.1038/35300

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

African trypanosomes are protozoan parasites that cause sleeping sickness in man. In addition to the axoneme, their flagellum contains a large structure called the paraflagellar rod (PFR) whose function is unknown. We used an antisense RNA approach to produce a specific molecular ablation of the PFR structure. The mutant cells are paralysed, demonstrating that the PFR has an essential role in cell motility.

引用

页码：548 / 548

页数：1

共 14 条

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