KSR and CNK:: two scaffolds regulating RAS-mediated RAF activation

被引:108
作者
Claperon, A.
Therrien, M.
机构
[1] Univ Montreal, Inst Res Immunol & Canc, Lab Intracellular Signaling, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, Dept Pathol & Biol Cellulaire, Montreal, PQ H2X 3J4, Canada
基金
加拿大健康研究院;
关键词
RAF; RAS; KSR; CNK; scaffold; signal transduction;
D O I
10.1038/sj.onc.1210408
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The RAS-RAF-MEK-extracellular-regulated kinase (RAS/ERK) pathway is a major intracellular route used by metazoan cells to channel to downstream targets a diverse array of signals, including those controlling cell proliferation and survival. Recent findings suggest that the pathway is assembled by specific scaffolding proteins that in turn regulate the efficiency, the location and/or the duration of signal transmission. Here, through the angle of studies conducted in Drosophila and C. elegans, we present two such proteins, the kinase suppressor of RAS (KSR) and connector enhancer of KSR (CNK) scaffolds, and highlight their implication in a novel mechanism regulating RAS-mediated RAF activation. Based on recent findings, we discuss the possibility that KSR, a RAF-like protein, does not solely act as a scaffold, but directly induces RAF catalytic function by a kinase-independent mechanism apparently shared by RAF-like proteins.
引用
收藏
页码:3143 / 3158
页数:16
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