Natural history of cardiac involvement in myotonic dystrophy: Correlation with CTG repeats

被引：35

作者：

Antonini, G

Giubilei, F

Mammarella, A

Amicucci, P

Fiorelli, M

Gragnani, F

Morino, S

Ceschin, V

Fragola, PV

Gennarelli, M

机构：

[1] Univ Rome La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

[2] Univ Rome La Sapienza, Dept Med Therapy, I-00185 Rome, Italy

[3] Univ Roma Tor Vergata, Dept Biopathol & Diagnost Imaging, Rome, Italy

来源：

NEUROLOGY | 2000年 / 55卷 / 08期

关键词：

D O I：

10.1212/WNL.55.8.1207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p < 0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.

引用

页码：1207 / 1209

页数：3

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