Homocysteic and homocysteine sulphinic acid exhibit excitotoxicity in organotypic cultures from rat brain

被引：28

作者：

Flott-Rahmel, B

Schurmann, M

Schluff, P

Fingerhut, R

Musshoff, U

Fowler, B

Ullrich, K

机构：

[1] Univ Hosp Muenster, Dept Paediat, Munster, Germany

[2] Univ Childrens Hosp Basel, Metab Unit, Basel, Switzerland

[3] Univ Muenster, Inst Physiol, Munster, Germany

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1998年 / 157卷 / Suppl 2期

关键词：

homocystinuria; excitotoxicity; organotypic cultures; Xenopus oocytes;

D O I：

10.1007/PL00014291

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The excitotoxic action of homocysteine and related sulphur-containing metabolites was investigated in organotpyic cultures derived from rat brain cortex and hippocampus by inhibition experiments using antagonists selective for different glutamate receptor subtypes. In addition the direct interaction of these metabolites with glutamate receptors expressed in frog oocytes was tested by conventional two electrode voltage clamp techniques. Conclusion Neurodegeneration and epilepsy observed in homocystinuria may be mediated by L-homocysteic and L-homocysteine sulphinic acid. Both metabolites exhibit exci totoxic potency by interaction with different glutamate receptor subtypes.

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页码：S112 / S117

页数：6

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