Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)

被引：72

作者：

Zhao, F

Watanabe, Y

Nozawa, H

Daikonnya, A

Kondo, K

Kitanaka, S

机构：

[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

[2] Kirin Brewery Co Ltd, Cent Labs Key Technol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 01期

关键词：

D O I：

10.1021/np0499113

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known prenylflavonoids (1-4) and a new prenylflavonoid (5), hulupinic acid (6), lupulone (7), and its six new derivatives (8-13) were isolated from the active fraction. The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined.

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页码：43 / 49

页数：7

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