Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

被引：418

作者：

Bertram, L

Blacker, D

Mullin, K

Keeney, D

Jones, J

Basu, S

Yhu, S

McInnis, MG

Go, RCP

Vekrellis, K

Selkoe, DJ

Saunders, AJ

Tanzi, RE

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol,Genet & Aging Unit, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat,Gerontol Res Unit, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[4] Johns Hopkins Univ, Inst Med, Dept Psychiat, Baltimore, MD 21287 USA

[5] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA

[6] Harvard Univ, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

SCIENCE | 2000年 / 290卷 / 5500期

关键词：

D O I：

10.1126/science.290.5500.2302

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades A beta, the principal component of beta -amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

引用

页码：2302 / +

页数：3

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