Type-4 pili and meningococcal adhesiveness

被引：36

作者：

Nassif, X ^{[1
]}

Marceau, M ^{[1
]}

Pujol, C ^{[1
]}

Pron, B ^{[1
]}

Beretti, JL ^{[1
]}

Taha, MK ^{[1
]}

机构：

[1] INST PASTEUR,UNITE NEISSERIA,F-75724 PARIS 15,FRANCE

来源：

GENE | 1997年 / 192卷 / 01期

关键词：

virulence; Neisseria; blood-brain barrier; endothelial cells; PilC;

D O I：

10.1016/S0378-1119(96)00802-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The ability to interact with non-phagocytic cells is a crucial virulence attribute of the meningococcus. Pili play a major role in this process and are the only means yet discovered by which capsulated bacteria may adhere to cells. Pilus-mediated adhesion is a two-step process which requires (i) the expression of the adhesin PilC1 and (ii) the expression of an appropriate pilin variant. Some pilin variants have the ability to modify the degree of adhesiveness through the formation of bundles of pili which increases bacteria-bacteria interactions.

引用

页码：149 / 153

页数：5

共 28 条

[1] APICELLA MA, 1990, PRINCIPLES PRACTICE, P1600
[2] PILI ON MENINGOCOCCI FROM PRIMARY CULTURES OF NASOPHARYNGEAL CARRIERS AND CEREBROSPINAL-FLUID OF PATIENTS WITH ACUTE DISEASE
DEVOE, IW
GILCHRIST, JE
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 141 (02) : 297 - 305
[3] MORPHOLOGICAL DIFFERENCES IN NEISSERIA-MENINGITIDIS PILI
GREENBLATT, JJ
FLOYD, K
PHILIPPS, ME
FRASCH, CE
[J]. INFECTION AND IMMUNITY, 1988, 56 (09) : 2356 - 2362
[4] NEISSERIA-GONORRHOEAE PILC EXPRESSION PROVIDES A SELECTIVE MECHANISM FOR STRUCTURAL DIVERSITY OF PILI
JONSSON, AB
PFEIFER, J
NORMARK, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) : 3204 - 3208
[5] PHASE VARIATION OF GONOCOCCAL PILI BY FRAMESHIFT MUTATION IN PILC, A NOVEL GENE FOR PILUS ASSEMBLY
JONSSON, AB
NYBERG, G
NORMARK, S
[J]. EMBO JOURNAL, 1991, 10 (02) : 477 - 488
[6] PILUS BIOGENESIS GENE, PILC, OF NEISSERIA-GONARRHOEAE - PILC1 AND PILC2 ARE EACH PART OF A LARGER DUPLICATION OF THE GONOCOCCAL GENOME AND SHARE UPSTREAM AND DOWNSTREAM HOMOLOGOUS SEQUENCES WITH OPA AND PIL LOCI
JONSSON, AB
RAHMAN, M
NORMARK, S
[J]. MICROBIOLOGY-SGM, 1995, 141 : 2367 - 2377
[7] HIGH ADHESIVENESS OF ENCAPSULATED NEISSERIA-MENINGITIDIS TO EPITHELIAL-CELLS IS ASSOCIATED WITH THE FORMATION OF BUNDLES OF PILI
MARCEAU, M
BERETTI, JL
NASSIF, X
[J]. MOLECULAR MICROBIOLOGY, 1995, 17 (05) : 855 - 863
[8] MEYER TF, 1990, ANNU REV MICROBIOL, V44, P451
[9] ROLES OF PILIN AND PILC IN ADHESION OF NEISSERIA-MENINGITIDIS TO HUMAN EPITHELIAL AND ENDOTHELIAL-CELLS
NASSIF, X
BERETTI, JL
LOWY, J
STENBERG, P
OGAORA, P
PFEIFER, J
NORMARK, S
SO, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) : 3769 - 3773
[10] ANTIGENIC VARIATION OF PILIN REGULATES ADHESION OF NEISSERIA-MENINGITIDIS TO HUMAN EPITHELIAL-CELLS
NASSIF, X
LOWY, J
STENBERG, P
OGAORA, P
GANJI, A
SO, M
[J]. MOLECULAR MICROBIOLOGY, 1993, 8 (04) : 719 - 725

← 1 2 3 →