Intestinal IgA synthesis: A primitive form of adaptive immunity that regulates microbial communities in the gut

被引：90

作者：

Suzuki, Keiichiro ^{[1
]}

Ha, Seon-ah ^{[1
]}

Tsuji, Masayuki ^{[1
]}

Fagarasan, Sidonia ^{[1
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Mucosal Immun Lab, Tsurumi Ku, Kanagawa 2300045, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 02期

关键词：

AID; anaerobes; B cell homing; gut homeostasis; intestinal IgA;

D O I：

10.1016/j.smim.2006.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our intestine is colonized by an impressive community of bacteria, that has profound effects on the immune functions. The relationship between gut microbiota and the immune system is one of reciprocity: bacteria have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues (GALT) plays a key role in shaping the repertoire of gut microbiota. In this review we discuss new insights into the role of IgA in the maintenance of immune homeostasis and the reciprocal interactions between gut B cells and intestinal bacteria. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：127 / 135

页数：9

共 79 条

[1] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[2] COMMON VARIABLE IMMUNODEFICIENCY SYNDROME AND NODULAR LYMPHOID HYPERPLASIA IN THE SMALL-INTESTINE [J].

BASTLEIN, C ;

BURLEFINGER, R ;

HOLZBERG, E ;

VOETH, C ;

GARBRECHT, M ;

OTTENJANN, R .

ENDOSCOPY, 1988, 20 (05) :272-275

[3] ALPHA-4-BETA-7-INTEGRIN MEDIATES LYMPHOCYTE BINDING TO THE MUCOSAL VASCULAR ADDRESSIN MADCAM-1 [J].

BERLIN, C ;

BERG, EL ;

BRISKIN, MJ ;

ANDREW, DP ;

KILSHAW, PJ ;

HOLZMANN, B ;

WEISSMAN, IL ;

HAMANN, A ;

BUTCHER, EC .

CELL, 1993, 74 (01) :185-195

[4] The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells [J].

Bowman, EP ;

Kuklin, NA ;

Youngman, KR ;

Lazarus, NH ;

Kunkel, EJ ;

Pan, JL ;

Greenberg, HB ;

Butcher, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (02) :269-275

[5] Regional specialization in the mucosal immune system: what happens in the microcompartments? [J].

Brandtzaeg, P ;

Baekkevold, ES ;

Farstad, IN ;

Jahnsen, FL ;

Johansen, FE ;

Nilsen, EM ;

Yamanaka, T .

IMMUNOLOGY TODAY, 1999, 20 (03) :141-151

[6]

BURT RW, 1999, TXB GASTROENTEROLOGY, P1995

[7]

BUTCHER EC, 1982, J IMMUNOL, V129, P2698

[8] B cell receptor signal strength determines B cell fate [J].

Casola, S ;

Otipoby, KL ;

Alimzhanov, M ;

Humme, S ;

Uyttersprot, N ;

Kutok, JL ;

Carroll, MC ;

Rajewsky, K .

NATURE IMMUNOLOGY, 2004, 5 (03) :317-327

[9]

Cebra J. J., 1994, HDB MUCOSAL IMMUNOLO, P151

[10]

Cebra JJ, 1999, AM J CLIN NUTR, V69, p1046S, DOI 10.1093/ajcn/69.5.1046s

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