Antiangiogenic therapy in brain tumor models

被引：25

作者：

Bernsen, HJJA

Van der Kogel, AJ

机构：

[1] Univ Nijmegen, Inst Radiotherapy, NL-6525 GA Nijmegen, Netherlands

[2] Canisius Wilhelmina Hosp, Dept Neurol, Nijmegen, Netherlands

来源：

JOURNAL OF NEURO-ONCOLOGY | 1999年 / 45卷 / 03期

关键词：

glioma model; antiangiogenesis; brain tumor vasculature;

D O I：

10.1023/A:1006395802727

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis of patients with malignant brain tumors remains poor despite new developments in neurosurgery, chemotherapy and radiotherapy. Malignant gliomas are highly vascularized, and there is ample evidence that their growth is angiogenesis-dependent. Therefore, new therapeutic approaches often include the inhibition of angiogenesis. In this review, experimental studies of antiangiogenic agents in brain tumor models are summarized. The results of these experiments as well as potential pitfalls in extrapolation to the clinic are discussed.

引用

页码：247 / 255

页数：9

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