Micro-patterned nanofibrous biomaterials

被引：15

作者：

Igarashi, Satoshi ^{[1
]}

Tanaka, Junzo ^{[1
]}

Kobayashi, Hisatoshi ^{[1
]}

机构：

[1] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2007年 / 7卷 / 03期

关键词：

nanofiber; scaffold; bioabsorbable polymer; poly(glycolide); tissue engineering;

D O I：

10.1166/jnn.2007.516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanofibrous materials made from bioabsorbable and biocompatible polymers have promising applications as tissue-engineered scaffolds. Genetic analysis of human umbilical vein endothelial cells (HUVEC) that attached to Poly(glycolide) (PGA) nanoifibrous materials prepared via electrospinning methods demonstrated high expression of Integrin v and VEGF receptor genes, which are known angiogenesis markers. In order to improve the function of the PGA nanofibrous materials for tissue engineering applications, we used a micro-patterned template instead of a flat collector in the electrospinning process. "Micro-patterned nanofibrous material" demonstrated uniformly sized dents with diameters of 200 micrometers and depths of 36 micrometers. The dents were regularly spaced, with a 250 micrometer space between two dents. These sizes are similar to that of the template. We will discuss further applications of this designable micro-patterned nanofibrous biomaterial.

引用

页码：814 / 817

页数：4

共 21 条

[1] ELECTROSTATIC SPINNING OF ACRYLIC MICROFIBERS [J].

BAUMGARTEN, PK .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1971, 36 (01) :71-+

[2] Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering [J].

Boland, ED ;

Telemeco, TA ;

Simpson, DG ;

Wnek, GE ;

Bowlin, GL .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2004, 71B (01) :144-152

[3] Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning [J].

Boland, ED ;

Wnek, GE ;

Simpson, DG ;

Pawlowski, KJ ;

Bowlin, GL .

JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2001, 38 (12) :1231-1243

[4] Processing and microstructural characterization of porous biocompatible protein polymer thin films [J].

Buchko, CJ ;

Chen, LC ;

Shen, Y ;

Martin, DC .

POLYMER, 1999, 40 (26) :7397-7407

[5] Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning [J].

Ding, B ;

Kimura, E ;

Sato, T ;

Fujita, S ;

Shiratori, S .

POLYMER, 2004, 45 (06) :1895-1902

[6]

Emig D., 2002, US Patent, Patent No. 6395046

[7] A review on polymer nanofibers by electrospinning and their applications in nanocomposites [J].

Huang, ZM ;

Zhang, YZ ;

Kotaki, M ;

Ramakrishna, S .

COMPOSITES SCIENCE AND TECHNOLOGY, 2003, 63 (15) :2223-2253

[8] Human bone marrow stromal cell responses on electrospun silk fibroin mats [J].

Jin, HJ ;

Chen, JS ;

Karageorgiou, V ;

Altman, GH ;

Kaplan, DL .

BIOMATERIALS, 2004, 25 (06) :1039-1047

[9] Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend [J].

Kenawy, ER ;

Bowlin, GL ;

Mansfield, K ;

Layman, J ;

Simpson, DG ;

Sanders, EH ;

Wnek, GE .

JOURNAL OF CONTROLLED RELEASE, 2002, 81 (1-2) :57-64

[10] Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques [J].

Kidoaki, S ;

Kwon, IK ;

Matsuda, T .

BIOMATERIALS, 2005, 26 (01) :37-46

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