Fabrication of paper-based microfluidic sensors by printing

被引：347

作者：

Li, Xu ^{[1
]}

Tian, Junfei ^{[1
]}

Garnier, Gil ^{[1
]}

Shen, Wei ^{[1
]}

机构：

[1] Monash Univ, Dept Chem Engn, Australian Pulp & Paper Inst, Melbourne, Vic 3800, Australia

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2010年 / 76卷 / 02期

关键词：

Microfluidic system; Ink jet printing; Paper; Sizing; LOW-COST; DEVICES;

D O I：

10.1016/j.colsurfb.2009.12.023

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A novel method for the fabrication of paper-based microfluidic diagnostic devices is reported; it consists of selectively hydrophobizing paper using cellulose reactive hydrophobization agents. The hydrophilic-hydrophobic contrast of patterns so created has excellent ability to control capillary penetration of aqueous liquids in paper channels. Incorporating this idea with digital ink jet printing techniques, a new fabrication method of paper-based microfluidic devices is established. Ink jet printing can deliver biomolecules and indicator reagents with precision into the microfluidic patterns to form bio-chemical sensing zones within the device. This method thus allows the complete sensor, i.e. channel patterns and the detecting chemistries, to be fabricated only by two printing steps. This fabrication method can be scaled up and adapted to use high speed, high volume and low cost commercial printing technology. Sensors can be fabricated for specific tests, or they can be made as general devices to perform on-demand quantitative analytical tasks by incorporating the required detection chemistries for the required tasks. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：564 / 570

页数：7

共 18 条

[1] Inkjet-printed microfluidic multianalyte chemical sensing paper [J].

Abe, Koji ;

Suzuki, Koji ;

Citterio, Daniel .

ANALYTICAL CHEMISTRY, 2008, 80 (18) :6928-6934

[2] Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: A proof of principle [J].

Blicharz, Timothy M. ;

Rissin, David M. ;

Bowden, Michaela ;

Hayman, Ryan B. ;

DiCesare, Christopher ;

Bhatia, Jasvinder S. ;

Grand-Pierre, Nerline ;

Siqueira, Walter L. ;

Helmerhorst, Eva J. ;

Loscalzo, Joseph ;

Oppenheim, Frank G. ;

Walt, David R. .

CLINICAL CHEMISTRY, 2008, 54 (09) :1473-1480

[3] Low-cost printing of poly(dimethylsiloxane) barriers to define microchannels in paper [J].

Bruzewicz, Derek A. ;

Reches, Meital ;

Whitesides, George M. .

ANALYTICAL CHEMISTRY, 2008, 80 (09) :3387-3392

[4]

DITRRICH PS, 2009, LAB CHIP, V9, P15

[5] THE EFFECT OF SURFACTANTS ON WICKING FLOW IN FIBER NETWORKS [J].

HODGSON, KT ;

BERG, JC .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1988, 121 (01) :22-31

[6] Liquid-paper interactions during liquid drop impact and recoil on paper surfaces [J].

Kannangara, Dushmantha ;

Zhang, Hailong ;

Shen, Wei .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 280 (1-3) :203-215

[7]

KIPPHAN FF, 2001, HDB PRINTING MEDIA, P55

[8] Quantitative biomarker assay with microfluidic paper-based analytical devices [J].

Li, Xu ;

Tian, Junfei ;

Shen, Wei .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (01) :495-501

[9] Paper-Based Microfluidic Devices by Plasma Treatment [J].

Li, Xu ;

Tian, Junfei ;

Nguyen, Thanh ;

Shen, Wei .

ANALYTICAL CHEMISTRY, 2008, 80 (23) :9131-9134

[10] Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay [J].

Lu, Yao ;

Shi, Weiwei ;

Jiang, Lei ;

Qin, Jianhua ;

Lin, Bingcheng .

ELECTROPHORESIS, 2009, 30 (09) :1497-1500

← 1 2 →