Facile one-pot synthesis of 4-Hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-sulfonic acid 1,1-dioxide

被引：35

作者：

Siddiqui, Waseeq A.

Ahmad, Saeed

Khan, Islam Ullah

Siddiqui, Hamid Latif

Weaver, George W.

机构：

[1] Appl Chem Res Ctr, PCISR Labs Complex, Lahore, Pakistan

[2] Gov Coll Univ, Dept Chem, Lahore, Pakistan

[3] Univ Punjab, Inst Chem, Lahore, Pakistan

[4] Univ Loughborough, Dept Chem, Loughborough, Leics, England

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 4-6期

关键词：

1,2-benzothiazine-3-sulfonic acid 1,1-dioxide; chloromethyl saccharin; hydroxymthyl saccharin; 2-methyl-4-oxo-1,2-benzothiazine; saccharin N-methanesulfonic acid;

D O I：

10.1080/00397910601131437

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a convenient synthesis of 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-sulfonic acid- 1, 1 -dioxide (6a) prepared in a novel one-pot reaction. The synthesis involves two transformations starting from 2-methyl-2H-1,2-benzothiazin4-(3H)-one 1,1-dioxide (7) with an overall yield better than that from the stepwise process, as well as the alternate procedure starting from saccharin (1). One-pot synthesis of an important intermediate, saccharin-N-methane sulfonic acid (4), is also described.

引用

页码：767 / 773

页数：7

共 11 条

[1]

[Anonymous], B KOREAN CHEM SOC

[2]

BUNTON CA, 1952, J CHEM SOC, P4541

[3] THE STEREOCHEMISTRY OF ALPHA-HALOKETONES .1. THE MOLECULAR CONFIGURATIONS OF SOME MONOCYCLIC ALPHA-HALOCYCLANONES [J].