The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease

被引：208

作者：

Cummings, JL

Back, C

机构：

[1] Univ Calif Los Angeles, Sch Med, Reed Neurol Res Ctr, Dept Neurol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 1998年 / 6卷 / 02期

关键词：

D O I：

10.1097/00019442-199821001-00009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A variety of neuropsychiatric symptoms occur in Alzheimer's disease (AD) including agitation, psychosis, depression, apathy, disinhibition, anxiety, purposeless behavior, and disorders of sleep and appetite. Neuropsychiatric symptoms have been related to cholinergic deficiency and improve after treatment with cholinomimetic agents. Cholinergic drugs are unique among psychotropic agents in exerting disease-specific and broad-spectrum effects. These observations provide the basis for the cholinergic hypothesis of the neuropsychiatric symptoms of AD, suggesting that the cholinergic deficit of AD contributes to the neuropsychiatric symptoms of AD and that cholinomimetic therapy ameliorates the behavioral disturbances accompanying AD.

引用

页码：S64 / S78

页数：15

共 72 条

[1]

[Anonymous], 1992, NEUROPSY NEUROPSY BE

[2]

[Anonymous], DEMENTIA

[3] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].