Abnormal RNA processing and altered expression of serin-rich proteins in minimal-change nephrotic syndrome

被引：5

作者：

Grimbert, P ^{[1
]}

Audard, V ^{[1
]}

Valanciute, A ^{[1
]}

Pawlak, A ^{[1
]}

Lang, P ^{[1
]}

Guellaën, G ^{[1
]}

Sahali, D ^{[1
]}

机构：

[1] Univ Paris 12, INSERM, Hop Henri Mondor, Serv Nephrol Adulte,AP HP,U581, F-94010 Creteil, France

来源：

PEDIATRIC RESEARCH | 2005年 / 57卷 / 01期

关键词：

D O I：

10.1203/01.PDR.0000148013.53429.5B

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Mechanisms underlying the pathophysiology of minimal-change nephrotic syndrome (MCNS), the most frequent glomerular disease in children, remain elusive, but recent findings argue for a T cell dysfunction. Starting from a differential cDNA library from T cells of a patient under relapse and remission, we identified 16 transcripts specific for MCNS. All of these transcripts that were selectively up-regulated during the relapse phase of the disease were generated by alternative splicing of known genes. This abnormal RNA expression was associated with a down-regulation of serin-rich protein 75 and serin-rich protein 40, two proteins involved in mRNA splicing. Taken together, these data suggest that T cell dysfunction in MCNS is associated with abnormal mRNA splicing.

引用

页码：133 / 137

页数：5

共 19 条

[1] B-cell and plasma-cell splicing differences: A potential role in regulated immunoglobulin RNA processing [J].