Synthetic study of aquayamycin. Part 3. First total synthesis

被引:66
作者
Matsumoto, T
Yamaguchi, H
Tanabe, M
Yasui, Y
Suzuki, K [1 ]
机构
[1] Tokyo Inst Technol, Dept Chem, Tokyo 1528551, Japan
[2] Japan Sci & Technol Corp, CREST, Tokyo 1528551, Japan
关键词
D O I
10.1016/S0040-4039(00)01480-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first total synthesis of aquayamycin (1) has been accomplished. The crucial steps include (I) the Hauser reaction between 3-(phenylsulfonyl)phthalide 3 and cyclohexenone 4 to make up the linear BCD tricycle, and (2) the intramolecular pinacol coupling of keto aldehyde 7 to the full tetracyclic framework. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码:8393 / 8396
页数:4
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